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Welcome to MEFS NEWS UPDATES, the digest of the top stories in Assisted Reproduction and Genetics, where we provide summaries of the week's news, announcements and recommendations on books, exhibitions and other events.     

 

  

 Edited by: Dr. Howaida Hashim

 

   

 

 

 

 

 

 

Announcement:

 

  • University of Oxford's new MSc in Clinical Embryology now recruiting for October 2009 entry

  • Clinical Fellowship in Andrology and Reproductive Medicine

  • News:

     

  • Welcome to ARABLAB 2009.... From: Dr. Howaida Hashim

  •  Assisted reproduction associated with elevated risk of birth defects

  • Overweight women more likely to miscarry healthy babies

  • Slow-frozen embryos seem to produce healthier babies in IVF [Correction]

  • Child born following whole ovary transplant                                                                                                                

  • Acupuncture does not increase chance of IVF conception: further evidence 

  • 'No-drugs' IVF just as effective for under 35's

  • Screening embryos before IVF improves success rate

  • Girl or boy? It's in dad's genes

  • Holding out hope for in-vitro funding

    With Quebec covering two $10,000 infertility treatments, Ontario's residents are looking to province for help

  • 10th International Congress on Reproductive Biomedicine
     

  •  Highlights from Fertility and Sterility

  • Limited Choices and Difficult Decisions for Patients with Frozen Embryos

  • Exposure to Cigarette Smoke Damages Eggs, Impairs Embryo Development 

  • Highlights from the 64th annual meeting of the american society for reproductive medicine 

  • Specialized assisted reproductive services are effective for HIV-infected patients who want to have children, but these services are not usually available at smaller clinics

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    Highlights from Fertility and Sterility

    Limited Choices and Difficult Decisions for Patients with Frozen Embryos

    In the largest, multisite study of fertility patients’ preferences for the future fate of their frozen embryos, researchers found that patients often prefer options that are not available to them and find existing options less than acceptable. 

    Anne Drapkin Lyerly, MD of Duke University Medical Center led a group of professionals surveying patients from nine geographically diverse fertility centers in the United States. One thousand and twenty individuals, women and men who had cryopreserved embryos in storage, answered a questionnaire addressing the likelihood of their choosing among seven options for their unneeded embryos. Five of the embryo disposition options were conventional: store for future reproduction; thaw and discard; donate to another couple; keep frozen indefinitely; and donate for research. Two options characterized as alternative were not actually offered at any of the clinics whose patients were surveyed: transfer to the woman’s body at an infertile time and a disposal ceremony. The patients also answered questions about their desire to have more children or not and considerations and concerns informing their choice of embryo disposition options.

    Most of the respondents (54%) said that they were very likely to use their embryos for future reproduction and 21% were very likely to donate them for research. Seven percent or fewer were very likely to choose any other option.

    Of the respondents who were certain that they did not want another baby (193 individuals), 41% considered research donation a very likely option, while only 16% considered reproductive donation a very likely option and 12% saw thaw and discard as a very likely option.

    The considerations that most influenced patients’ preferences included: wanting to help find cures for diseases; not wanting someone else to raise one’s genetic child; the feeling that thawing and discarding embryos is wasteful; and one’s partner’s opinion about what to do with the embryos.

    In analyzing the data, the researchers found that nearly half of the stored embryos were not, at the time of the survey, intended to be used for reproduction, but that the alternatives were not especially appealing to patients, who tended to prefer options not generally available- like research donation- and reject options that are available- such as reproductive donation and thawing and discarding embryos.

    Certain demographic factors were predictive of patients’ plans for their embryos. Childless patients were highly likely to intend to use their embryos for a future pregnancy. Patients who had stored their embryos for five years or more were more likely to express the intention to thaw and discard them or to keep them frozen indefinitely than those who had embryos in storage for a shorter period of time.

    “Patients preparing for an IVF cycle are completely focused on the immediate goal of achieving pregnancy,” noted Elizabeth Ginsburg, MD, President of the Society for Assisted Reproductive Technology. “As clinicians, we need to give patients more information and more real choices concerning what they can do with the embryos that may remain after they complete their families. It’s a difficult decision that patients have to make but we can help them by discussing with new patients the ramifications of embryo freezing and by regularly reminding patients who have stored embryos of the choices available to them.”

    Lyerly et al, Fertility patients’ views about frozen embryo disposition: results of a multi-institutional U.S. survey, Fertility and Sterility, in press December 4, 2008.


    The American Society for Reproductive Medicine, founded in 1944, is an organization of over 8000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology. Affiliated societies include the Society for Assisted Reproductive Technology, the Society for Male Reproduction and Urology, the Society for Reproductive Endocrinology and Infertility, and the Society of Reproductive Surgeons.

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Exposure to Cigarette Smoke Damages Eggs, Impairs Embryo Development 

     

    Cigarette smoke has deleterious effects on the health and development of eggs and embryos. Doctors from Florida and China collaborated on a study using mice as a model to test the hypothesis that smoking induces oxidative stress, cell death and dysfunction, and the shortening of telomeres- the DNA at the ends of chromosomes that protect them from degradation. 

    The researchers found that, while similar numbers of eggs were collected from exposed, subject mice and control mice, the eggs of mice exposed to cigarette smoke or cigarette smoke condensate (CSC) for four weeks were more likely than the controls’ to show increased fragmentation and delayed fertilization, resulting in impaired embryo development in vitro. The fragmented eggs also showed oxidative stress and embryos from mice exposed to smoke or CSC four weeks before fertilization were more likely to contain dead cells and altered expression of Oct4, a protein that plays a crucial role in the formation of blastocycts with a functional inner cell mass. 

    The relationship between cigarette smoke or CSC and embryo development was dependant on the length of time animals were exposed. However, embryos exposed to smoke for as little as four days showed reduced telomere length in cells and decreased blastocyst development, suggesting that embryos may be more sensitive to smoke-induced oxidative stress than eggs. 

    “Here is even more evidence demonstrating the dreadful effects smoking has on reproductive tissues and function. While there are some data implying that the effects may not be permanent, every woman planning to become pregnant would be wise to quit smoking or, better yet, never start,” advises William Gibbons, MD, President-Elect of ASRM. 

    Huang et al, Effect of cigarette smoke on fertilization and embryo transfer. Fertility and Sterility in press, November 2008.

     

     

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    HIGHLIGHTS FROM THE 64th ANNUAL MEETING OF THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE 

    Specialized Assisted Reproductive Services are Effective for HIV-Infected Patients Who Want to Have Children, but These Services Are Not Usually Available at Smaller Clinics

    San Francisco, California – Many of the estimated six million people in the US infected with HIV, Hepatitis B (HBV) or Hepatitis C (HCV) are of reproductive age. Those desiring to have children and minimize the possibility of passing their virus to their offspring need access to specialized advanced reproductive technologies. 

    Researchers at Texas Tech University Health Sciences Center found that while services are available, they are most likely to be delivered at larger clinics. To gauge availability, they sent a survey to 370 assisted reproductive technology (ART) programs listed on the website of the Centers for Disease Control. Forty-seven programs responded, with 13 reporting that they offered no services for patients infected with HIB, HBV, and HCV. Seven more clinics did not treat patients with HIV. Generally, the clinics which did not offer treatment options for virally-infected patients were smaller and cited a lack of appropriate equipment.

    In Canada, HIV positive couples and individuals have access to advanced reproductive technologies at more than half of fertility clinics; but the more technically demanding the service, the more difficult it is to obtain.

    Mark Yudin, MD and his colleagues in Toronto sent surveys to all 28 fertility clinics in Canada. Twenty responded, with 16 clinics being willing to serve HIV-positive patients, four unwilling. 

    Of the 16 clinics, 12 had seen one or more HIV-positive male or female in the previous year. Sixty percent of clinics responding (12/20) offered intrauterine insemination (IUI) when the woman was HIV-positive and donor sperm for HIV-positive females – 30% (6/20) offered sperm washing for HIV-positive males – and 20% (4/20) offered IVF for couples with an HIV-positive female.

    In New York, doctors at Columbia University report on their successful multidisciplinary approach to providing IVF for HIV-positive women. Before starting ovulation induction, patients are required to go through an extensive evaluation of their disease and overall health, a psychosocial evaluation, and a consultation with a specialist in Maternal Fetal Medicine who has a special interest in HIV. The program has also adapted its surgical and lab protocols to isolate potentially infectious tissues, using a separate operating room for retrievals, and removing granulosa cells that surround the eggs which can harbor blood.

    Forty patients, from 27 to 42 years old, who had been diagnosed with HIV an average of 7 years earlier, were evaluated – 25 were treated. Most were on highly active antiretroviral therapy and their HIV levels were undetectable prior to starting fertility treatment. Of the eight women who had ovulation induction and IUI, four became pregnant and delivered babies. Seventeen women had IVF with 10 becoming pregnant and seven delivering; three of the IVF pregnancies ended in miscarriage. All of the babies, tested at birth, three months and six months are HIV-negative.

    David Adamson, MD, President of ASRM remarked, “For most patients HIV is a manageable, chronic disease and HIV- positive men and women live full lives which can include the joys of parenthood. The Columbia program is a good example of what can be achieved when reproductive specialists partner with their colleagues in maternal-fetal medicine and infectious disease specialists. With the participation of all of these specialties, we can help patients become parents and prevent the transmission of virus to infants.”

    ·     O-120 Diaz et al – Assisted Reproductive Technologies Available to Individuals with Human Immunodeficiency Virus and other Communicable Diseases

    ·     P-810 Yudin et al – Advanced Reproductive Technologies for HIV-Positive Individuals and Couples in Canada

    ·     P-289 Douglas et al – A Systematic, Multidisciplinary Approach to Address the Reproductive Needs of HIV-Seropositive Women 

    Note: All information is embargoed until the time of presentation at the meeting, unless otherwise indicated.


    The American Society for Reproductive Medicine, founded in 1944, is an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology. Affiliated societies include the Society for Assisted Reproductive Technology, the Society for Male Reproduction and Urology, the Society for Reproductive Endocrinology and Infertility and the Society of Reproductive Surgeons.

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Announcement:

     

     

     

     

    University of Oxford's new MSc in Clinical Embryology now recruiting for October 2009 entry
    This new, one year, residential, taught M.Sc. aims to provide graduate students, scientists and clinicians with highly advanced theoretical and practical understanding of human reproductive biology, embryology, infertility and assisted reproductive technology (ART) along with intensive ‘hands-on’ practical training in essential laboratory skills and the sophisticated gamete micromanipulation techniques associated with ART.
    Source: Bionews  October 2008

     

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Clinical Fellowship in Andrology and Reproductive Medicine

    Dr.N.Pandiyan, Chettinad Health City
    20 December 2008

     

    Objectives: 

    Train postgraduate students to establish and run an efficient, cost effective and ethical reproductive medicine unit.

    At the end of the course, candidates will

    1. be able to handle reproductive medical problems both in the male and female.

    2. have good working knowledge in the field of infertility and reproductive laboratory services

    Eligibility:

    Postgraduate Degree or Diploma in Obstetrics and Gynecology, General surgery, urology and general medicine.

    Duration:

    1 year

    Mode of Teaching:

    Lectures, Power point presentations and interactive sessions

    Practical demonstrations

    Hands on – wherever applicable

    Journal club every month

    Frequent examinations conducted throughout the course. MCQ’s, Short notes and Essay type Questions.

    The students will not receive any stipend or any other form of financial support from the institution. However they may utilize the existing infrastructure in the department and institution. Fellows enrolled will not be on call in the hospital in any other department.

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    From: Dr. Howaida Hashim

    Welcome to ARABLAB 2009.....

    I have pleasure enclosing below details of the " ARABLAB 2009 Seminar Program" which starts on 10th January with over 50+ seminars covering many different aspects of the Analytical Industry.

    Please visit our website,
    www.arablab.com, and click on tab ‘Seminars’.  You can then click on the seminar you are interested in attending, and contact the presenter direct with any questions you may have..

    The Seminar Program is always very popular and very well attended, so make sure that you make a "diary note" to attend the ARABLAB Show and register for the seminar on your arrival.

    If you want information on hotel availability in Dubai , visit
    www.arablab.com and click on "THE LATEST HOTEL INFORMATION" for current availability.

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Assisted reproduction associated with elevated risk of birth defects


    A study published last week in the journal Human Reproduction found an elevated risk of birth defects amongst babies conceived through assisted reproductive techniques, including IVF. The research, headed by Dr Jennita Reefhuis of the US Centre for Disease Control and Prevention, used data from the National Birth Defects Prevention Study to compare the health of babies born to women who had used the techniques with infants born to women who had conceived naturally.
    Source: Bionews November 2008

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Overweight women more likely to miscarry healthy babies


    Overweight women are at greater risk of miscarrying a genetically normal baby in the early stages of pregnancy than women who maintain a healthy weight, according to a new study by scientists at the Stanford University School of Medicine in California, US.
    Source: Bionews November 2008

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Slow-frozen embryos seem to produce healthier babies in IVF [Correction]


    Three new independent studies have provided further evidence that embryos stored using slow-freezing techniques may be better than fresh for IVF. The studies were presented at the American Society for Reproductive Medicine conference in San Francisco, US, last week. The studies indicate that using frozen embryos rather than fresh embryos reduces the risk of stillbirth and premature delivery.
    Source: Bionews November 2008

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Child born following whole ovary transplant

    A 39-year old woman has become the first to give birth following a whole ovary transplant. Susanne Butscher received an intact ovary from her fertile twin sister last year, during a landmark operation carried out by Dr Sherman Silber of the Infertility Centre of St Louis, Missouri US. Mrs Butscher became infertile after her ovaries failed at the age of 15. To date, eight women have given birth subsequent to receiving small sections of ovarian tissue. Yet this - the ninth case - has been lauded as a pioneering achievement in infertility treatment.

    The birth of baby Maja last week should be celebrated, according to Dr Silber, during what he has labelled an 'infertility epidemic' that in the UK alone is affecting upwards of 100,000 women. Although a complicated procedure (the operation involves the reattachment of arteries one third of a millimetre in diameter), the transplant renews the ability to conceive naturally. It also restores hormone levels to those necessary for driving the menstrual cycle. Such hormones, like oestrogen and progesterone, also protect against osteoporosis. 

    Nonetheless, the majority of women affected by an early menopause are unlikely to have a fertile twin sister capable of donating an ovary. This would be necessary in order to avoid donor-rejection of foreign tissue, and to circumvent the need for immuno-suppressive drugs. But Dr Silber claims that, from a social perspective, it will be an attractive option for women wishing to extend fertility into their forties and fifties, perhaps to favour a career. However the British Fertility Society (BFS) is opposed to what it calls an 'unethical application' of the operation, suggesting current methods, like egg storage, are less problematic. Laurence Shaw, consultant in reproductive medicine at the London Bridge Fertility Centre, London, and spokesperson for the BFS, said: 'I would have thought that the long-term freeze-storing of an ovary would cause as much harm as the deterioration due to age itself'.

    The BFS instead endorses a more practical application of the operation. Women that face invasive cancer therapies like radiotherapy and chemotherapy (both of which reduce fertility) could have an ovary frozen pending an improvement in their condition. In such cases, ovary storage could be more suitable than egg extraction, as egg follicles must first be matured through a lengthy hormone treatment, causing unwanted delays to chemotherapy.

    Resource: Bionews November 2008

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Acupuncture does not increase chance of IVF conception: further evidence


    Two new studies have found that acupuncture does not increase the chances of conception through IVF.

     

    The first study was conducted by Prentice Women's Hospital in Chicago, and was presented at the American Society for Reproductive Medicine conference in San Francisco, and the second was published in the journal Human Reproduction. 

    For the Prentice Women's Hospital study, led by Irene Moy, 124 women were split into two groups. One group was given real acupuncture, while the other was given 'sham' acupuncture, both before and after embryo implantation. The patients undergoing sham acupuncture had needles inserted into the body, but not at known acupuncture points. Of the women taking part in the study, 43.9% given genuine acupuncture conceived, while 55.2% of those given sham acupuncture conceived. 

    The study published in Human Reproduction took place at the Department of Obstetrics and Gynaecology at the University of Hong Kong, where real and sham acupuncture was given to 370 patients. In this study the sham acupuncture used a placebo needle, which gave the appearance and sensation of piercing the skin, but was blunt and retracted into the handle of the needle when pressed on the skin. The ensuing pregnancy rate for sham acupuncture patients was 55.1% versus 43.8% for real acupuncture. 
    Source: Bionews,  November 2008

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    'No-drugs' IVF just as effective for under 35's


    A new method of assisted conception has been hailed as a safer and equally effective alternative to IVF for certain groups of women undergoing treatment.

     

    The Oxford Fertility Centre revealed this week that of the 40 women they treated between February 2007 and March 2008 with in-vitro maturation (IVM), the nine successful cases were all among the 27 women under 35; a success rate of 33 per cent. Conventional IVF has a 31 per cent success rate for this group of women. 

    IVM does not require the powerful hormonal drugs used in IVF which stimulate the ovaries to produce mature eggs; instead, immature eggs are removed without the use of drugs and matured in the laboratory before being fertilised. As fewer drugs are used, the cost of IVM would be significantly less than IVF, £1,700 compared with around £4,300.

    The IVM process promises to be safer than IVF because it does not risk the potentially fatal ovarian hyperstimulation syndrome (OHSS), a build up of fluid in the lungs and abdomen sometimes triggered by the hormonal drugs involved. This news will be particularly welcome to women with polycystic ovary syndrome (PCOS), which affects 10 to 20 per cent of women, and who are at higher risk of developing OHSS. 

    'Unstimulated IVM treatment is a viable alternative to standard IVF for women under 35 years of age who have ovaries of a polycystic morphology', said Dr Tim Child, of the Oxford Fertility Centre, who presented the research at the American Society of Reproductive Medicine conference in San Francisco. 'IVM avoids the potentially fatal complication of OHSS in this at-risk patient group.' Dr Child attributed the significant improvement in success rates for IVM to better laboratory procedures and patient selection. 'I'm not sure we will ever get better than IVF but the aim is to achieve the same success rate', he said.

    Another patient group who may benefit from IVM is
    cancer patients due to undergo chemotherapy. Tumours can be worsened by the hormonal drugs used in IVF, whereas the removal and storage of immature eggs in the IVM process would not adversely affect cancer patients and enable them to use their stored eggs once in remission.

    Geeta Nargund from St George's Hospital in South London said that the technique is not appropriate for older women since fewer eggs remain in their ovaries. Many eggs fail to mature in the laboratory and so a higher number of eggs are needed to begin with.

    Source: Bionews November 2008

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Screening embryos before IVF improves success rate


    The first trial of a procedure which selects IVF embryos with the best chance of developing into healthy babies was presented last week at the American Society for Reproductive Medicine conference in San Francisco.
    Source: Bionews Nov. 2008

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Girl or boy? It's in dad's genes

    Alison Cranage
    Progress Educational Trust
    16 December 2008

     

    [BioNews, London]

    New research hints that whether a man has sons or daughters is influenced by his genes. The study, by Mr Correy Gellatly from Newcastle University, was published in the journal Evolutionary Biology last week.

    Mr Gellatly looked at 927 family trees from Europe and North America, detailing over 556,387 people, dating back to 1600. He observed that a man with many brothers is more likely to have sons, while a man with many sisters is likely to have more daughters. This effect was not seen in women.

    The sex of a baby is determined by its father's sperm, an 'X' sperm (after the version of the sex chromosome it carries) makes a girl and a 'Y' sperm a boy. Mr Gellatly hypothesises that there is a gene, only active in males but a version of which is inherited from both parents, which determines the ratio of X and Y sperm a man produces.

    He also suggests such a gene could explain the increase in baby boys being born after World War I. Mr Gellatly explains that the odds were in favour of men with more sons seeing a son return from the war. This would mean such men were likely to have sons, a trait inherited from their father. In contrast men with more daughters may have lost their only sons in the war, and those sons would have been more likely to father girls. 

    Other explanations have been proposed as to why the birth rate is not 50:50 in certain couples. It has been suggested that the sex of a baby could be influenced by differences in the time in a woman's monthly cycle sex happens, or the amount of time sperm spends in the testicles. Mr Galletly's study indicates there is a genetic component.

    He says the net effect of such a gene is to balance out the population: 'If there are too many males in the population, for example, females will more easily find a mate, so men who have more daughters will pass on more of their genes, causing more females to be born in subsequent generations.'



    http://www.BioNews.org.uk
    BioNews@progress.org.uk

     

     

     


     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Holding out hope for in-vitro funding

     

    With Quebec covering two $10,000 infertility treatments, Ontario's residents are looking to province for help

    December 27, 2008

    Tanya Talaga

    QUEEN'S PARK BUREAU

    Premier Jean Charest promised shortly before he was re-elected in Quebec last month to publicly fund two in-vitro fertilization treatments for women unable to conceive.

    Now, some Ontario residents are holding out hope their government will follow Quebec's lead and live up to a promise made last year.

    The Liberal government, in the November 2007 throne speech, pledged it would do all it could to help Ontarians start a family. As a start, it created an expert panel on infertility and adoption, a group of nearly a dozen people touched by these issues, to examine and recommend ways to make adoption and fertility treatment more accessible and affordable.

    The group has posted an online survey asking for people to share their experiences until Jan. 12 at Ontario.ca/creating families. The panel is expected to report back to Minister of Children and Youth Services Deb Matthews.

    It is estimated one in six Ontario couples experience fertility problems. Ontario only pays for in-vitro fertilization treatments – a process in which eggs are fertilized outside the womb then transferred back – for women with completely blocked fallopian tubes.

    Some believe this funding is discriminatory and should be amended to reflect Ontario's universal health-care model.

    "The cost is minimal compared to some of the other stuff we do," said Dr. Matt Gysler, a Mississauga obstetrician and gynecologist and chief of medical staff at Credit Valley Hospital. One IVF treatment is roughly $10,000.

    Gysler points to intensive care costs or the price of cancer medications that prolong life for mere months at a cost of $30,000.

    "Intensive care, end-of-life care, is very expensive," he said. "I'm not saying people don't deserve that. We have no problems paying a huge amount on that side."

    But Gysler argues that children become productive members of society. "I can't see how this could ever become a losing prospect for society," he said in an interview.

    In Israel, the government funds as many IVF treatments as needed for women up to age 45; in Britain, the cost of one treatment is funded.

    In the more than 20 years Gysler has practised medicine, he has seen a rise in infertility because so many women delay childbirth until they are older, more financially sound and set in good careers.

    "It is quite phenomenal in southern Ontario," he said.

    After age 35, fertility begins to decline. By 43, even with IVF treatment, the chances of a pregnancy are very slim.

    Infertility takes a devastating emotional toll on a couple, Gysler said. "People massively underestimate the significance infertility has on those women. When you meet them, you realize instantly this is really a disease state," he said.

    To some cultures, having children is incredibly important, said Gysler, who, in his practice, sees many diverse Ontarians living in the Brampton and Mississauga area.

    "Take a young Pakistani couple who is working hard in this country – having a child is really fundamental to their existence," he said. "I think it is imprinted on our genetic material. The species needs to reproduce in order to continue to exist."

    After years of trying to get pregnant, Lisa Ellies knew when she turned 35 that something was wrong. She went through six years of various assisted reproductive techniques, took medications, endured inter-uterine inseminations and had several surgeries. Finally, at 42, she became pregnant with twins after an IVF treatment. She lost one of the babies but gave birth to Alexa.

    Last June, the Whitby mom did one other round of IVF in a last-ditch effort to conceive. In total, she has spent $55,000 on the procedures.

    "I really do think this should be funded," said Ellies. "I understand you need limitations – there are women who have done 10 rounds at $100,000 and they are still going."

    On average, it takes about two and a half IVF rounds before a woman becomes pregnant, said Ellies, who added perhaps the government should consider funding two or three treatments.

    Toronto's Danny and Jillian Roth went through five rounds of IVF in four years and spent "more money than I care to remember," said Danny Roth. "You keep thinking the next one will work," he said. But it didn't. The couple experienced "unexplained" infertility problems, something that affects about 10 per cent of couples.

    The Roths eventually turned to adoption. In 2004 they adopted their son, who is now 4.

    "We are thrilled the McGuinty government made it part of the election platform and formed the (provincial) panel," said Roth, who is both on the Ontario panel and a board member of the Infertility Awareness Association of Canada.

    Roth never dreamed of having infertility problems.

    Most couples feel that, he said. It is a shock when life doesn't work the way you thought it would.

    "It is all-consuming," he said. "We know couples whose marriages didn't survive it. We know couples who didn't buy a house because they put their money in fertility treatments."

    Roth wants infertile couples to share their story. The infertility association hopes to collect 10,000 stories to give to Matthews and Minister of Health David Caplan before the release of the panel's final report. Visit www.iaac.ca and click on "Share Your Story."

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    10th International Congress on Reproductive Biomedicine

    By Kamal Alizadeh, Royan Institute
    23 December 2008

     

    10th Congress on Reproductive Biomedicine Sep 23-25, 2009 - Tehran - Iran In Collaboration: Science and Technology Deputy of the President of Islamic Republic of Iran Iranian Society of Reproductive Medicine (ISRM) European Society of Human Reproduction and Embryology (ESHRE) Middle East Fertility Society (MEFS) Dear Colleagues, Following nine successful Royan International Congresses, tenth congress will be held on September 23-25, 2009 in Tehran, Iran.

     

    During the past congresses we observed participation of thousands of specialists, scientists, researchers and students from all around the world in a friendly atmosphere to exchange the knowledge and experiences. Their warm encouragements plus their brilliant comments and suggestions led us to increase in scientific level and better organization of the congress. Although the congress name is Royan, but belongs to all scientists and doctors from all around the world working in fields of reproduction and stem cells, specially Iranian scientists and prominent professors from various universities, research centers and clinics who mostly are pioneers in the congress fields, and without their support we could not hold it properly. Considering all the above said experiences for past one decade, I believe in better incoming congress with higher scientific level. Iran is an ancient country full of unique historical monuments and astonishing natural landscapes. International guests have the opportunity to get familiar with this ancient culture along with their scientific work. There will be an interesting social program in this regard. I must also thank my colleagues in Royan Institute for their great effort especially Dr. Ashraf Moini, with her science and knowledge and great experiences for accepting the chair of this congress, and welcome you all in advance to this high level scientific congress. Hamid Gourabi Ph.D. Congress President Topics: Embryology Andrology Infertility & ART Reproductive Health & Epidemiology Reproductive Physiology & Immunology Reproductive Imaging Reproductive Genetics & PGD Menopause Ethics

    http://www.royaninstitute.org